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Although ICOS scientists were non testing chemical compound IC351 for treating ED, they recognized its likely utility for treating that perturb. Soon, in 1994, ICOS standard a evident for compound IC351 (structurally unequal sildenafil citrate and vardenafil), and Stage 1
clinical trials began in 1995. In 1997, the Phase angle 2 clinical studies were initiated for males experiencing ED, and then progressed to the Form 3 trials that supported the drug's FDA commendation.